FORMERLY BLISSFUL MOOD

Mood is

serotonin chemistry.

5-HTP is the direct serotonin precursor. SAM-e is the universal methyl donor. GABA calms the over-firing brain. DMAE and ashwagandha round out a stack designed for mood stability under real-world stress — not a sedative blanket.

Shop Mood Plus View Formula →

PROFESSIONAL GRADE · 60 CAPSULES · 5-HTP · SAM-E · GABA · ASHWAGANDHA

Mood Plus bottle
SEROTONIN
25 mg 5-HTP per capsule

Feed the precursor.

5-Hydroxytryptophan is the immediate precursor to serotonin — one metabolic step away from the neurotransmitter that governs mood, appetite, and sleep. Derived from Griffonia simplicifolia seed, the botanical source nature uses.

METHYL DONOR
SAM-e + niacinamide + magnesium

Methylation meets mood.

S-Adenosyl Methionine is the universal methyl donor that underwrites serotonin, dopamine, and melatonin synthesis. Paired with magnesium ascorbate and niacinamide — the cofactors mood chemistry depends on.

DAILY DOSE
2 capsules daily, split

One AM, one PM.

Adults take one capsule twice daily. Ashwagandha and chamomile soften the stress response. DMAE supports cognitive tone. GABA quiets the over-firing that drives anxiousness. Mood chemistry, layered.

MAY BENEFIT

Mood is a
neurochemistry problem.

01
Serotonin support
5-HTP is the direct precursor to serotonin — the neurotransmitter most tied to emotional regulation.
02
Stress resilience
Ashwagandha is a Rasayana adaptogen that supports healthy cortisol and HPA axis tone.
03
Calm focus
GABA lowers neuronal excitability without sedation — a brake on anxious over-firing.
04
Restful sleep
Serotonin converts to melatonin at night — repletion supports the upstream chemistry of sleep.
05
Methylation backbone
SAM-e donates methyl groups for serotonin and dopamine synthesis — a layered approach to mood.
06
Nervous-system comfort
Chamomile and magnesium ascorbate support the parasympathetic tone behind feeling settled.

Formula

Eight ingredients. Layered mood chemistry.

KEY INGREDIENTS

Niacin
as Niacinamide · 30 mg · 188% DV
Magnesium
as Magnesium Ascorbate · 75 mg · 18% DV
Gamma-Aminobutyric Acid (GABA)
100 mg
Ashwagandha Root Extract
5% Withanolides · 30 mg
Chamomile Flower 4:1 Extract
25 mg
5-Hydroxytryptophan (5-HTP)
from Griffonia Simplicifolia Seed Extract · 25 mg
Dimethylaminoethanol Bitartrate (DMAE Bitartrate)
25 mg
S-Adenosyl Methionine (SAM-e)
10 mg

OTHER INGREDIENTS

Microcrystalline cellulose, hypromellose (capsule), natural vanilla flavor, silicon dioxide, ascorbyl palmitate.

DIRECTIONS

Adults: Take one capsule twice daily or as directed by your healthcare practitioner.

Mood Plus supplement facts
MAY BENEFIT:
Anxiousness
Mood & Relaxation
Sleep
Stress

Questions

Frequently asked.

Can I take Mood Plus with an SSRI or other antidepressant?
Do not combine 5-HTP or SAM-e with SSRIs, MAOIs, tricyclics, or migraine medications without direct clinician supervision. The combination can raise serotonin to levels that cause serotonin syndrome, a serious condition. If you take psychiatric medication, discuss interactions with your prescriber before starting.
Who is Mood Plus designed for?
Adults looking for botanical and amino-acid support for mood stability, stress resilience, and healthy sleep — especially those not on prescription SSRIs. It's a common choice in functional-medicine protocols for patients whose mood complaints track with methylation weakness or chronic stress.
How long before I notice a change?
Many patients report steadier mood and calmer stress response within two to three weeks. Ashwagandha and adaptogenic effects build over six to eight weeks. Evaluate the formula over a month of consistent use rather than judging it in the first few days.
Can I take it during the day without feeling sedated?
Yes — the formula is designed for calm focus, not sedation. DMAE contributes cognitive tone, and the GABA dose is supportive rather than heavy. That said, individual responses vary; start with one capsule in the AM and add the second dose in the afternoon or evening once you know how you respond.
Is it safe during pregnancy?
No — do not use if pregnant or lactating. Several ingredients (5-HTP, SAM-e, ashwagandha, St. John's wort-adjacent serotonergic support) are not recommended in pregnancy. Consult a healthcare practitioner before use if you suspect you may be pregnant.
Can children take Mood Plus?
Only under the direct guidance of a healthcare practitioner. The serotonergic components require careful dosing for pediatric patients and should be used with professional oversight, not as a self-directed choice.

The Science

Learn the why.

methylation

How methylation shapes mood, focus, and energy

Mood, focus, and energy aren't separate systems — they run on the same methyl groups. Here's how the methylation cycle underwrites neurotransmitter chemistry, mitochondrial output, and the difference between a good day and a flat one.

Apr 4, 2026 →

hormones

COMT polymorphisms and stress: the "warrior vs worrier" gene

COMT clears dopamine and norepinephrine from your prefrontal cortex. One common polymorphism changes the speed — and shapes how you perform under stress. Here's what the research shows.

Apr 2, 2026 →

sleep

Methylation and sleep: how the methyl cycle shapes your night

Your ability to fall asleep, stay asleep, and recover overnight is partly a methylation problem. Here's how the methyl cycle connects to circadian rhythm, melatonin production, and the chemistry of restorative sleep.

Feb 21, 2026 →