TOPICAL CALMING CREAM

Calm, through

Name: Calming Cream
Brand: Neurobiologix
SKU: NBXA168
Price: 48.95 USD
Availability: InStock

the skin.

A lavender-based cream that delivers GABA, 5-HTP, L-Theanine, and magnesium transdermally. Built for the genetic variants that make GABA hard to produce — for bedtime, overstimulation, and sensory overload.

Shop Calming Cream View Formula →

Purchases are completed at Neurobiologix, the seller. Gene Direct Nutrition may earn a commission.

PROFESSIONAL GRADE · 90 PUMPS · GABA · 5-HTP · L-THEANINE

TRANSDERMAL

90 pumps per bottle

Delivered through the skin.

A lavender-oil base built for maximum skin absorption — bypassing the gut entirely. The cream dries quickly and is applied to thin-skin areas where delivery is fastest.

NEUROCHEMISTRY

4 calming cofactors

GABA, 5-HTP, theanine, magnesium.

GABA is the brain's primary inhibitory neurotransmitter. 5-HTP is the serotonin precursor. L-Theanine promotes alpha-wave calm. Magnesium lactate-gluconate rounds out the relaxation chemistry.

SLEEP & SENSORY

1 pump, 30 min before bed

For bedtime or overstimulation.

Adults use 1–2 pumps as needed; children use 1/2 to 1 pump at bedtime or during hyperactivity. Maximum four applications per day. Apply to thin, hairless skin.

MAY BENEFIT

Relaxation is
chemistry, not willpower.

Sleep onset

GABA and 5-HTP support the inhibitory and serotonergic pathways that govern falling asleep.

Nervousness

L-Theanine promotes alpha brain waves associated with calm focus and lower physiological tension.

Hyperactivity

Transdermal GABA supports the inhibitory side of the excitatory/inhibitory balance in sensitive kids.

Sensory overload

Magnesium lactate-gluconate supports nervous system regulation under sensory stress.

Mood stability

5-HTP feeds serotonin synthesis, which supports stable mood through the day.

MTHFR / GABA genetics

Useful for patients with genetic variants that limit endogenous GABA production.

Formula

Four calming cofactors in a transdermal lavender base.

KEY INGREDIENTS

Water

Magnesium Lactate-Gluconate

Hydroxyethylacrylate/Sodium Acryloyldimethyltaurate Copolymer

Squalane

Polysorbate 60

Caprylic/Capric Triglycerides

Glycerin

Lecithin

Dimethicone

L-Theanine

Phenoxyethanol

5-Hydroxytryptophan

5-HTP

Gamma-Aminobutyric Acid

GABA

Sodium Phytate

Vitamin E

D-Alpha Tocopherol

Xanthan Gum

Lavandula Angustifolia Oil

OTHER INGREDIENTS

Water (reverse osmosis), emulsifier blend (hydroxyethylacrylate/sodium acryloyldimethyltaurate copolymer, squalane, polysorbate 60), caprylic/capric triglycerides, glycerin, lecithin (from sunflower), dimethicone, L-Theanine, phenoxyethanol, 5-HTP (5-hydroxytryptophan), GABA, magnesium (as magnesium lactate-gluconate), citric acid, sodium phytate, vitamin E (d-alpha tocopherol), xantham gum, lavandula angustifolia (lavender) essential oil.

DIRECTIONS

Adults: **Adults:** **1-2 pumps** as needed or as recommended by your healthcare professional. Always consult your healthcare professional if you have questions or concerns about these ingredients.

MAY BENEFIT:

Anxiousness

Sensory Issues

Children's Health

Mood & Relaxation

Sleep

Stress

Questions

Frequently asked.

Why topical instead of a capsule?

Oral GABA has poor bioavailability and uncertain blood-brain barrier crossing. A transdermal cream bypasses gut absorption entirely, which many practitioners prefer for children and patients with GI issues. The lavender base was chosen for its skin absorption properties.

Who is this formula designed for?

Adults and children dealing with bedtime difficulty, nervousness, sensory issues, or hyperactivity — particularly those with genetic variants (like GAD1) that reduce endogenous GABA production. It was developed for sensitive patients who don't tolerate oral sedative formulas well.

Can I use it on children?

Yes. The label directs 1/2 to 1 pump for children at bedtime or during hyperactivity or nervousness, or as directed by a healthcare practitioner. For sleep support, apply about 30 minutes before bed.

Where do I apply it?

Thin-skin areas without hair — inner wrists, inner forearms, behind the knees, or the neck. Avoid bathing for 30 minutes after application to give the active ingredients time to absorb.

How often can I reapply?

Do not exceed four applications per day. Adults use 1–2 pumps as needed; most people find a single evening application sufficient for sleep support.

Is it safe during pregnancy or breastfeeding?

Consult your healthcare practitioner before use if you are pregnant or lactating. 5-HTP in particular is not routinely recommended during pregnancy without medical oversight.

The Science

Learn the why.

methylation

How methylation shapes mood, focus, and energy

Mood, focus, and energy aren't separate systems — they run on the same methyl groups. Here's how the methylation cycle underwrites neurotransmitter chemistry, mitochondrial output, and the difference between a good day and a flat one.

Apr 4, 2026 →

hormones

COMT Val158Met and stress: what “warrior vs worrier” gets wrong

COMT rs4680 can influence catecholamine metabolism, but it does not determine a personality or prescribe a supplement. See what human stress research actually supports.

Apr 2, 2026 →

sleep

Methylation and sleep: how the methyl cycle shapes your night

Your ability to fall asleep, stay asleep, and recover overnight is partly a methylation problem. Here's how the methyl cycle connects to circadian rhythm, melatonin production, and the chemistry of restorative sleep.

Feb 21, 2026 →