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Methylation
is the

quiet engine.

Complete Bioactive B-Vitamins Support for the one in three Americans whose genetics hinder the conversion of folic acid to methylfolate.

Shop Methylation Complete™ View Ingredients →

Checkout is at Neurobiologix, the seller. Gene Direct Nutrition may earn a commission.

PROFESSIONAL GRADE · 120 DISSOLVABLE TABLETS · VEGETARIAN FRIENDLY

Methylation Complete Bottle
Delivery System
B12 Methylcobalamin
B6 Pyridoxal 5'-Phosphate
5-MTHF Quatrefolic®

Bioactive, not synthetic.

Pre-converted cofactors bypass the genetic bottleneck — no MTHFR guesswork.

NERVOUS + IMMUNE UPLINK
_

Live benefits.

Real-time systemic support mapped to your body's essential pathways.

Daily Protocol
M
T
W
T
F
S
S

Once daily. Dissolves fast.

Fast-dissolving tablets — ideal for vegetarians, post-surgical recovery, or GI-compromised patients.

Most supplements focus on: dosing folic acid and hoping your body converts it.

We focus on:
methylation that actually reaches the cell.

Self-Check · 60 seconds

Is this you?

Answer 8 quick questions. We'll tell you whether your profile fits the methylation pattern — and send a personalized guide to your inbox.

Tired even after a full night of sleep
Brain fog or trouble concentrating
Anxiety, low mood, or irritability
Trouble falling or staying asleep
Sensitive to alcohol, caffeine, or medications
Take (or have taken) folic acid supplements
Family history of depression, heart disease, or miscarriage
Confirmed or suspected MTHFR gene variant

0 / 8 answered

The Protocol

01 / RECOGNIZE

MTHFR Variants

Roughly 1 in 3 Americans carry MTHFR variants that stall the methylation cycle.

02 / DELIVER

Direct Absorption

Fast-dissolving tablets release B12, B6, and 5-MTHF directly into the bloodstream.

03 / RESTORE

Downstream Flow

Supports mood, focus, sleep, hormones, and glutathione production — the downstream of methylation.

Formula

Transparent clinical dosing without unnecessary fillers.

KEY INGREDIENTS

Vitamin B6
(Pyridoxal 5'-Phosphate)
Folate
(L-Methyltetrahydrofolate Calcium Salt + Quatrefolic® 6S-5-MTHF Glucosamine Salt)
Vitamin B12
(Methylcobalamin + Hydroxycobalamin)

OTHER INGREDIENTS

Sorbitol, Mannitol, Flavors, Croscarmellose Sodium, Stearic Acid, Silicon Dioxide, Ascorbyl Palmitate.

Supplement Facts
MAY BENEFIT:
Energy
Focus & Attention
Methylation (Cell Function)
Immune System

Questions

Frequently asked.

What is methylation and why does it matter?
Methylation is a biochemical process your body performs billions of times per second — transferring a methyl group between molecules. It regulates over 200 downstream processes including neurotransmitter synthesis, DNA repair, hormone balance, immune function, and detoxification. When methylation stalls, everything downstream slows with it.
How do I know if I need Methylation Complete™?
Common signals include persistent fatigue, brain fog, anxiety or low mood, poor sleep, sensitivity to caffeine or medications, elevated homocysteine, and a family history of MTHFR variants. Our 60-second Self-Check on this page is a quick way to gauge likelihood. For certainty, an MTHFR genetic test (covered in our GenePro+ panel) gives a definitive answer.
What makes Methylation Complete™ different from a regular B-complex?
Three things. Every B is pre-converted to its active (methylated) form — B12 as methylcobalamin, folate as 5-MTHF, B6 as pyridoxal-5-phosphate — so your body doesn't have to activate them. It's sublingual, so the tablet dissolves under your tongue and bypasses your stomach for better absorption. And it's dosed for clinical support, not RDA minimums.
Is Methylation Complete™ safe to take during pregnancy?
Bioactive 5-MTHF is specifically recommended during pregnancy, especially for women with MTHFR variants who can't convert folic acid efficiently. That said, every pregnancy is individual — always consult your OB, midwife, or functional medicine practitioner before starting any new supplement during pregnancy.
When should I take it?
Directions recommend one tablet in the morning and one in the afternoon — taken 2 to 3 hours before bedtime. B vitamins can be energizing, so late-night dosing isn't ideal. Let each tablet fully dissolve under your tongue (1–3 minutes) rather than swallowing.
How long before I feel a difference?
Many people notice shifts in energy, mood, or mental clarity within 2 to 4 weeks. Full methylation-cycle adaptation can take 6 to 12 weeks. If you have a significant MTHFR variant and are new to methylated Bs, start slow — some people experience a brief adjustment period as the pathway opens up.
Can I take this alongside other supplements or medications?
Methylation Complete™ pairs well with most wellness stacks. Note that high-dose folate can interact with methotrexate (used for autoimmune conditions), certain anticonvulsants, and some chemotherapies. Always share your supplement list with your prescribing physician.
Is it vegetarian?
Yes. The tablets are vegetarian-friendly and free of common allergens. Full formulation is listed in the Supplement Facts above.

Peer-reviewed support

The research behind methylation.

Methylation Complete is built on decades of peer-reviewed research into MTHFR genetics, the one-carbon cycle, and the active coenzyme forms of folate, B12, and B6. The citations below represent a sample of the literature informing our formulation choices.

  1. [01]

    Liew SC, Gupta ED. Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: epidemiology, metabolism and the associated diseases. Eur J Med Genet. 2015;58(1):1-10.

    PMID: 25449138
  2. [02]

    Tsang BL, Devine OJ, Cordero AM, et al. Assessing the association between the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and blood folate concentrations: a systematic review and meta-analysis of trials and observational studies. Am J Clin Nutr. 2015;101(6):1286-1294.

    PMID: 25788000
  3. [03]

    Pietrzik K, Bailey L, Shane B. Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet. 2010;49(8):535-548.

    PMID: 20608755
  4. [04]

    Scaglione F, Panzavolta G. Folate, folic acid and 5-methyltetrahydrofolate are not the same thing. Xenobiotica. 2014;44(5):480-488.

    PMID: 24494987
  5. [05]

    Froese DS, Fowler B, Baumgartner MR. Vitamin B12, folate, and the methionine remethylation cycle-biochemistry, pathways, and regulation. J Inherit Metab Dis. 2019;42(4):673-685.

    PMID: 30693532
  6. [06]

    Ueland PM, McCann A, Midttun O, Ulvik A. Inflammation, vitamin B6 and related pathways. Mol Aspects Med. 2017;53:10-27.

    PMID: 27593095
  7. [07]

    Liwinski T, Lang UE. Folate and its significance in depressive disorders and suicidality: a comprehensive narrative review. Nutrients. 2023;15(17):3859.

    PMID: 37686891
  8. [08]

    Obeid R, Holzgreve W, Pietrzik K. Is 5-methyltetrahydrofolate an alternative to folic acid for the prevention of neural tube defects? J Perinat Med. 2013;41(5):469-483.

    PMID: 23482308

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

STOP GUESSING. START KNOWING.

Want to know what nutrition

you actually need?

GENEPRO+ NUTRIGENOMICS TEST

Among 8 billion people, each individual possesses a unique genetic blueprint that determines how their body processes nutrients and maintains cellular health. GenePro+ analyzes over 100 markers across eleven wellness categories, transforming complex genetic data into actionable clinical insights with a simple buccal swab.

This advanced assessment enables healthcare providers to develop personalized wellness strategies based on each patient's specific genetic variations. From methylation pathways to metabolic function, GenePro+ delivers the precision understanding necessary for targeted supplementation and evidence-based interventions tailored to individual genetic expression.

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Checkout is at Neurobiologix, the seller. Gene Direct Nutrition may earn a commission.

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