FORMERLY METHYL FOLATE PRO

Methylfolate,

already active.

Targeted, high-dose bioactive B9 for the 1 in 3 Americans whose MTHFR genetics stall folic acid conversion. L-5-MTHF + folinic acid — the two forms your body can actually use.

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PROFESSIONAL GRADE · 90 VEGETARIAN CAPSULES · L-5-MTHF + FOLINIC ACID

Methyl Folate Plus™ bottle
CLINICAL DOSE
9,770 mcg DFE · 2,443% DV

Therapeutic, not token.

Most folate supplements dose at RDA levels. Methyl Folate Plus™ delivers practitioner-grade folate engineered for patients who actually need it.

BIOACTIVE FORMS
2 active folate paths

Two doors, not one.

L-5-MTHF (the form your cells use) plus folinic acid (a reserve pool the body converts as needed). Covers both usage modes the body draws on.

COFACTOR STACK
B2 + B3 cofactors included

The cycle, supported.

Riboflavin-5-Phosphate and niacinamide power the enzymes that use folate. Without them, even the best folate stalls out.

MAY BENEFIT

Methylation reaches
farther than you think.

01
Mood stabilization
Supports neurotransmitter synthesis tied to balanced mood.
02
Mental focus
Fuels the cognitive side of methylation — clarity, attention, recall.
03
Healthy sleep cycles
Circadian rhythm depends on methylation of melatonin precursors.
04
Immune function
Methylation regulates immune cell production and response.
05
Cellular detoxification
Folate feeds glutathione — the body's primary detox pathway.
06
Cardiovascular support
Clears homocysteine, a flag for cardiovascular risk.

Formula

Clinical dosing. Clean carriers. Nothing extra.

KEY INGREDIENTS

Vitamin B2
Riboflavin-5-Phosphate · 30 mg · 2,308% DV
Vitamin B3
Niacinamide · 125 mg NE · 781% DV
Folate
L-5-Methyltetrahydrofolate Calcium Salt + Folinic Acid Calcium Salt · 9,770 mcg DFE · 2,443% DV

OTHER INGREDIENTS

Hypromellose (capsule), Rice Flour, Ascorbyl Palmitate, Silicon Dioxide.

DIRECTIONS

Adults: 1 capsule twice daily, ideally in the morning and early afternoon.

Best taken alongside a methylation support product containing methyl B12.

Methyl Folate Plus™ supplement facts
MAY BENEFIT:
Methylation (Cell Function)

Questions

Frequently asked.

Who should take Methyl Folate Plus™?
This is a targeted, high-dose folate formula designed for patients who need clinical-level bioactive B9 support — often those with confirmed MTHFR variants, methylation challenges, elevated homocysteine, or neurological conditions tied to folate metabolism. It's typically recommended under practitioner guidance rather than as a general wellness supplement.
What's the difference between L-5-MTHF and folic acid?
Folic acid is the synthetic form found in fortified foods and basic supplements — your body must convert it to active 5-MTHF via the MTHFR enzyme. If you have an MTHFR variant (roughly 1 in 3 people do), this conversion is impaired and unused folic acid can accumulate. L-5-MTHF is the pre-converted, bioactive form — no enzymatic conversion required.
Why does this include both L-5-MTHF and folinic acid?
They work through slightly different channels. L-5-MTHF is the active methylated form ready for immediate use in methylation. Folinic acid feeds a reserve pool that the body routes into multiple folate-dependent pathways as needed. Providing both covers a wider range of folate activity.
Do I really need to pair it with Methylation Complete™?
Functionally, yes. Folate hands its methyl group to B12, which then delivers it into the methylation cycle. Without adequate active B12 (methylcobalamin), the folate you take can stall — and in sensitive individuals this can cause symptoms. Methylation Complete™ provides the exact B12 cofactor needed.
Isn't 9,770 mcg DFE a lot? Is that safe?
It's a clinical dose — significantly higher than basic supplement folate, designed for patients who actually need therapeutic-level support. For most adults the dose is well-tolerated, but anyone new to methylated folate should start under practitioner guidance, especially if an MTHFR variant is confirmed.
Can I take Methyl Folate Plus™ during pregnancy?
Bioactive folate is specifically beneficial during pregnancy, but dose matters. A 9,770 mcg DFE formula is well above the standard prenatal folate recommendation. Always consult your OB or functional medicine practitioner before adding this during pregnancy or while trying to conceive.
Can too much methylfolate cause side effects?
Sensitivity reactions — irritability, anxiety, insomnia, or headaches — can occur in people who "open up" methylation faster than their pathway is ready for, especially those with significant MTHFR variants. Starting at a lower dose or alternating days often resolves this. If symptoms persist, work with a practitioner.
When should I take it?
The label directs one capsule twice daily. B vitamins are energizing, so take it earlier in the day (morning and early afternoon) rather than at night. Best taken alongside a methylation support product containing methyl B12.

The Science

The folate primer.

nutrition

5-MTHF vs folic acid: what's the difference and which should you take?

Folic acid and 5-MTHF sound interchangeable. They're not. Here's how each one behaves in your body, why the distinction matters — especially for MTHFR carriers — and how to choose.

Feb 28, 2026 →

nutrition

Folate forms compared: 5-MTHF vs folinic acid vs folic acid

Three folate forms sit on supplement shelves under similar names. Their biology is very different. Here's how 5-MTHF, folinic acid, and folic acid behave in the body, and which one belongs in your stack.

Feb 11, 2026 →

methylation

B12, folate, and the remethylation pathway

B12 and folate are the pair that keeps homocysteine from piling up — and keeps your methylation cycle producing SAM-e. Here's how the remethylation pathway actually works, why both vitamins have to be present in active form, and what the data says about testing and support.

Feb 1, 2026 →

BUILT TO STACK

Folate needs a partner.

Methylfolate does the heavy lifting — but B12 is the cofactor that actually delivers the methyl group to the cycle. Pair Methyl Folate Plus™ with Methylation Complete™ for the full pathway.

Methyl Folate Plus™
THIS PRODUCT

Methyl Folate Plus™

High-dose L-5-MTHF + folinic acid + B2/B3 cofactors. The folate side of the methylation cycle for patients with confirmed MTHFR variants.

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Methylation Complete™
PAIRS WITH

Methylation Complete™

Sublingual B12 Methylcobalamin + B6 P5P + 5-MTHF. The daily methylation pathway support for MTHFR-affected patients.

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Peer-reviewed support

The science of bioactive folate.

Selected peer-reviewed research on L-5-methyltetrahydrofolate, folinic acid, and the riboflavin/niacinamide cofactors that support the folate and methionine cycles.

  1. [01]

    Scaglione F, Panzavolta G. Folate, folic acid and 5-methyltetrahydrofolate are not the same thing. Xenobiotica. 2014;44(5):480-488.

    PMID: 24494987
  2. [02]

    Pietrzik K, Bailey L, Shane B. Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet. 2010;49(8):535-548.

    PMID: 20608755
  3. [03]

    Bailey SW, Ayling JE. The pharmacokinetic advantage of 5-methyltetrahydrofolate for minimization of the risk for birth defects. Sci Rep. 2018;8(1):4096.

    PMID: 29511242
  4. [04]

    Ismail S, Eljazzar S, Ganji V. Intended and unintended benefits of folic acid fortification-a narrative review. Foods. 2023;12(8):1612.

    PMID: 37107407
  5. [05]

    McNulty H, Strain JJ, Hughes CF, Ward M. Riboflavin, MTHFR genotype and blood pressure: a personalized approach to prevention and treatment of hypertension. Mol Aspects Med. 2017;53:2-9.

    PMID: 27720779
  6. [06]

    Menezo Y, Elder K, Clement A, Clement P. Folic acid, folinic acid, 5 methyl tetrahydrofolate supplementation for mutations that affect epigenesis through the folate and one-carbon cycles. Biomolecules. 2022;12(2):197.

    PMID: 35204698
  7. [07]

    Froese DS, Fowler B, Baumgartner MR. Vitamin B12, folate, and the methionine remethylation cycle-biochemistry, pathways, and regulation. J Inherit Metab Dis. 2019;42(4):673-685.

    PMID: 30693532
  8. [08]

    Pissios P. Nicotinamide N-methyltransferase: more than a vitamin B3 clearance enzyme. Trends Endocrinol Metab. 2017;28(5):340-353.

    PMID: 28291578

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.