PRODUCT DOSSIER · FORMERLY METHYL FOLATE PRO
Methyl Folate Plus™
label facts.
Methyl Folate Plus™ is the current name of Methyl Folate Pro. The current label lists L-5-MTHF and folinic acid calcium salts, riboflavin-5-phosphate, and niacinamide in a 90-capsule bottle.
Purchases are completed at Neurobiologix, the seller. Gene Direct Nutrition may earn a commission.
90 CAPSULES · SERVING SIZE 1 CAPSULE · SKU NBXA170
One capsule per serving.
The current Supplement Facts panel lists a serving size of one capsule and 90 servings per container.
Two folate salts are listed.
The label identifies L-5-methyltetrahydrofolate calcium salt and folinic acid calcium salt as the folate sources.
Forms and amounts, not promises.
The label lists riboflavin as riboflavin-5-phosphate and niacin as niacinamide. See the full panel below.
Full label facts
Transcribed from the current Supplement Facts panel. Amounts are per one-capsule serving.
KEY INGREDIENTS
OTHER INGREDIENTS
Hypromellose (capsule), Rice Flour, Ascorbyl Palmitate, Silicon Dioxide.
DIRECTIONS
Adults: Take one capsule twice daily or as directed by your healthcare professional.
Copied from the current seller listing; this is label information, not a personal recommendation.
Product questions
What the label can answer.
Is Methyl Folate Plus™ the same product name as Methyl Folate Pro?
What is listed on the current Supplement Facts panel?
Why does the formula list both L-5-MTHF and folinic acid?
How does MTHFR relate to folate forms?
Are there clinical studies of Methyl Folate Plus™ itself?
How does the current seller direct people to take it?
Does the formula include vitamin B12?
Who should discuss this label with a healthcare professional?
The Science
The folate primer.
nutrition
5-MTHF vs folic acid: what's the difference and which should you take?
Folic acid and 5-MTHF sound interchangeable. They're not. Here's how each one behaves in your body, why the distinction matters — especially for MTHFR carriers — and how to choose.
Feb 28, 2026 →nutrition
Folate forms compared: 5-MTHF vs folinic acid vs folic acid
Three folate forms sit on supplement shelves under similar names. Their biology is very different. Here's how 5-MTHF, folinic acid, and folic acid behave in the body, and which one belongs in your stack.
Feb 11, 2026 →methylation
B12, folate, and the remethylation pathway
B12 and folate are the pair that keeps homocysteine from piling up — and keeps your methylation cycle producing SAM-e. Here's how the remethylation pathway actually works, why both vitamins have to be present in active form, and what the data says about testing and support.
Feb 1, 2026 →RELATED FORMULA
Folate and B12 are evaluated together.
Methyl Folate Plus™ does not list vitamin B12. Neurobiologix sells B12-containing formulas separately, but whether products should be combined depends on personal context and practitioner guidance.
Methyl Folate Plus™
A 90-capsule formula listing L-5-MTHF, folinic acid, riboflavin-5-phosphate, and niacinamide on the current label.
Checkout is at Neurobiologix, the seller. Gene Direct Nutrition may earn a commission.
Methylation Complete™
Sublingual B12 Methylcobalamin + B6 P5P + 5-MTHF. The daily methylation pathway support for MTHFR-affected patients.
Checkout is at Neurobiologix, the seller. Gene Direct Nutrition may earn a commission.
Ingredient background
What the research covers—and what it does not.
These papers discuss folate forms, nutrient biology, and related pathways. They are not clinical trials of Methyl Folate Plus™ as a finished formula and do not establish a personal treatment result.
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[01]
Scaglione F, Panzavolta G. Folate, folic acid and 5-methyltetrahydrofolate are not the same thing. Xenobiotica. 2014;44(5):480-488.
PMID: 24494987 -
[02]
Pietrzik K, Bailey L, Shane B. Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet. 2010;49(8):535-548.
PMID: 20608755 -
[03]
Bailey SW, Ayling JE. The pharmacokinetic advantage of 5-methyltetrahydrofolate for minimization of the risk for birth defects. Sci Rep. 2018;8(1):4096.
PMID: 29511242 -
[04]
Ismail S, Eljazzar S, Ganji V. Intended and unintended benefits of folic acid fortification-a narrative review. Foods. 2023;12(8):1612.
PMID: 37107407 -
[05]
McNulty H, Strain JJ, Hughes CF, Ward M. Riboflavin, MTHFR genotype and blood pressure: a personalized approach to prevention and treatment of hypertension. Mol Aspects Med. 2017;53:2-9.
PMID: 27720779 -
[06]
Menezo Y, Elder K, Clement A, Clement P. Folic acid, folinic acid, 5 methyl tetrahydrofolate supplementation for mutations that affect epigenesis through the folate and one-carbon cycles. Biomolecules. 2022;12(2):197.
PMID: 35204698 -
[07]
Froese DS, Fowler B, Baumgartner MR. Vitamin B12, folate, and the methionine remethylation cycle-biochemistry, pathways, and regulation. J Inherit Metab Dis. 2019;42(4):673-685.
PMID: 30693532 -
[08]
Pissios P. Nicotinamide N-methyltransferase: more than a vitamin B3 clearance enzyme. Trends Endocrinol Metab. 2017;28(5):340-353.
PMID: 28291578
*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.