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Practitioner-grade · MTHFR-aware
Methylation
Methylation is one of the most-studied biochemical processes in modern nutrition, and also one of the most misunderstood. Every second, your body transfers methyl groups (CH₃) onto DNA, neurotransmitters, hormones, and toxins — a process that regulates gene expression, helps the liver clear estrogen, builds serotonin and dopamine, and buffers the cardiovascular system against homocysteine damage.
The cycle is simple to draw but brittle in practice. It depends on a narrow set of cofactors (folate, B12, B6, betaine), on intact genes (MTHFR, MTR, BHMT, COMT, CBS), and on the absence of depleting factors like oxidative stress or alcohol. When any link is weak, the whole pathway slows.
The articles below walk through the cycle one step at a time: what each cofactor does, how B12 and folate move methyl groups together, what SAMe does downstream, and how to test whether your own methylation is working. If you're new to the topic, start with "The methylation cycle, explained" and then read the cofactor-specific pieces.
In this guide
methylation
SAM-e is the molecule your cells actually use to perform methylation — the universal methyl donor that sits downstream of B12, folate, and methionine. Here's what it does, the research behind it in mood and liver health, and where supplementation fits.
Apr 9, 2026 →methylation
Mood, focus, and energy aren't separate systems — they run on the same methyl groups. Here's how the methylation cycle underwrites neurotransmitter chemistry, mitochondrial output, and the difference between a good day and a flat one.
Apr 4, 2026 →methylation
MTHFR is the most famous gene in the methylation cycle — and often the least useful in isolation. Here's what a real methylation workup looks like: the genes that matter, the functional markers that catch what genetics miss, and how to read them together.
Mar 10, 2026 →methylation
Methylation runs in every cell, every second of your life. Here's what the cycle actually does — from activating folate to building dopamine — and why it's the quietest system in the body until it isn't.
Feb 13, 2026 →methylation
B12 and folate are the pair that keeps homocysteine from piling up — and keeps your methylation cycle producing SAM-e. Here's how the remethylation pathway actually works, why both vitamins have to be present in active form, and what the data says about testing and support.
Feb 1, 2026 →