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A field guide to your pathways.

Research-cited guides to MTHFR, folate metabolism, nutrigenomics, and the pathways that connect nutrient forms with everyday biology.

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Topic guides

Start with a volume.

Vol. 01 · MTHFR & genetics

The gene that affects 1 in 3 Americans.

Everything you need to understand MTHFR — what the gene does, which variants matter, how to test for them, and what to do if you carry one.

9 articles

Vol. 02 · Methylation

The quiet biochemistry behind everything.

Methylation drives DNA expression, neurotransmitter synthesis, detoxification, and immune regulation. This guide covers the cycle and the cofactors that run it.

5 articles

Vol. 03 · Mood & Mental Health

Brain chemistry starts with methyl.

Serotonin, dopamine, and melatonin all depend on methylation. This guide covers the nutrigenomic angle on mood, sleep, focus, and stress resilience.

5 articles

Vol. 04 · Pregnancy & Hormones

The methylation-fertility connection.

Folate status drives neural tube development; estrogen is cleared through methylation pathways. Read why MTHFR matters in pregnancy and hormonal balance.

4 articles

Vol. 05 · Nutrition Foundations

Not all B-vitamins are created equal.

The forms of B12, B9, B6, and D3 on your supplement label determine how well your body can use them. This guide explains bioactive vs. synthetic forms.

7 articles

All articles

Journal index.

32 articles · newest first

Catecholamines, tyrosine, and the chemistry of motivation Vitamin D cofactors: why D3 alone isn't enough P5P vs pyridoxine HCl: vitamin B6 forms, conversion, and safety Glutathione: the master antioxidant, explained SAM-e and the universal methyl donor: why it matters Phases of liver detox: glucuronidation, sulfation, methylation, and taurine conjugation How methylation shapes mood, focus, and energy COMT Val158Met and stress: what “warrior vs worrier” gets wrong MTHFR symptoms: what carriers actually notice day-to-day SAM-e vs SSRIs: what the comparison literature says Epigenetics vs genetics: what diet can actually change Methylation and the immune system: how one cycle shapes inflammation Estrogen methylation: how COMT and MTHFR shape hormone balance Supplements to avoid if you have MTHFR What is nutrigenomics? A plain-English guide to DNA-based nutrition Vitamin B12 forms compared: methyl, hydroxo, cyano, and adenosyl B12 Methylation testing: what to look for beyond MTHFR Why methylation matters for mood — the biochemistry behind it How to get tested for MTHFR (and what the results mean) What is MTHFR? A plain-English guide to the gene that affects 1 in 3 Americans 5-MTHF vs folic acid: what's the difference and which should you take? Homocysteine: what drives it up, what brings it down MTHFR and homocysteine: the connection that actually matters Methylation and sleep: how the methyl cycle shapes your night Which nutrition SNPs matter? MTHFR, B12, vitamin D, iron, and more Folate in pregnancy: why form and dose matter more than you think The methylation cycle, explained — from DNA to neurotransmitters Folate forms compared: 5-MTHF vs folinic acid vs folic acid Melatonin and MTHFR: the connection you weren't told about MTHFR and miscarriage: what the research actually shows MTHFR and pregnancy: what matters before and during B12, folate, and the remethylation pathway
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