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FORMERLY PREGNENOLONE PLUS PRO

The upstream

steroid precursor.

Pregnenolone is the molecule the body converts into DHEA, cortisol, estrogen, progesterone, and testosterone. Forty milligrams per capsule, paired with niacinamide — a focused formula developed by neuro-immune specialist Dr. Kendal Stewart.

Shop Pregnenolone Plus View Formula →

Purchases are completed at Neurobiologix, the seller. Gene Direct Nutrition may earn a commission.

PROFESSIONAL GRADE · 60 CAPSULES · PREGNENOLONE · NIACINAMIDE

Pregnenolone Plus bottle
PRECURSOR
40 mg pregnenolone per capsule

Upstream of every steroid hormone.

Pregnenolone sits at the top of the steroid hormone cascade. It is the raw material the adrenals and gonads convert into DHEA, cortisol, progesterone, estrogen, and testosterone — a single molecule that touches the whole system.

NEURO-STEROID
2 brain receptor systems

A molecule the brain makes too.

Pregnenolone is also a neurosteroid, synthesized in the brain and active at NMDA and GABA-A receptors. That is the biology behind its roles in learning, memory, alertness, mood stability, and sleep architecture.

DAILY DOSE
1 capsule in the AM

One capsule, morning.

One capsule in the AM or as directed by a practitioner. Niacinamide (75 mg) pairs alongside pregnenolone as a supporting cofactor — the whole protocol is meant to be run with clinical oversight.

MAY BENEFIT

Hormones share
an upstream source.

01
Energy and resilience
As the precursor to cortisol and DHEA, pregnenolone sits upstream of the adrenal response to daily demand.
02
Memory and cognition
Neurosteroid activity at NMDA receptors is part of the biology behind learning and memory consolidation.
03
Mood stability
GABA-A modulation contributes to the calming, anxiolytic side of pregnenolone's neurosteroid profile.
04
Sleep architecture
Neurosteroids influence the sleep-related inhibitory circuits that support deeper, more restorative rest.
05
Inflammation signaling
Pregnenolone's anti-inflammatory profile has been studied in the context of neuro-immune dysregulation.
06
Hormonal foundation
A single upstream substrate the body can route toward whichever downstream hormone is depleted.

Formula

Two ingredients. Upstream of the whole hormone cascade.

KEY INGREDIENTS

Niacin
as Niacinamide · 75 mg NE · 469% DV
Pregnenolone
40 mg · †† DV

OTHER INGREDIENTS

Vegetable cellulose, ascorbyl palmitate, rice flour, silicon dioxide.

DIRECTIONS

Adults: Take one capsule in the AM daily or as your healthcare practitioner recommends.

Pregnenolone Plus supplement facts
MAY BENEFIT:
Women's Health
Hormone Balance
Inflammation

Questions

Frequently asked.

How is pregnenolone different from DHEA or testosterone?
Pregnenolone is the raw material the body converts into those hormones. DHEA, cortisol, estrogen, progesterone, and testosterone are all downstream of pregnenolone in the steroidogenesis pathway. Supplementing upstream lets the body route the substrate toward whichever hormone is depleted — rather than pushing a specific downstream molecule.
Who is this formula designed for?
Adults working with a practitioner on adrenal recovery, hormonal balance, cognitive sharpness, or sleep and mood complaints — particularly in a neuro-immune framework. Because pregnenolone sits upstream of the entire steroid cascade, it is a formula to use with medical oversight, not to self-prescribe indefinitely.
Why is niacinamide included?
Niacinamide (75 mg NE) is the non-flushing form of vitamin B3 and a supporting cofactor in this formulation. Beyond its role in cellular energy metabolism, it pairs with pregnenolone in the broader neuro-immune protocol Dr. Stewart designed this formula around.
When should I take it?
One capsule in the AM. Pregnenolone is upstream of cortisol, and the body's cortisol rhythm peaks in the morning — aligning the dose with that natural curve tends to support daytime energy without interfering with evening wind-down.
Can I take this alongside DHEA or thyroid support?
Work with a practitioner who can run labs. Pregnenolone, DHEA, and thyroid interact across endocrine axes, and stacking them without monitoring can tip the balance in unintended directions. Targeted testing and dose adjustment matter more here than they do with most supplements.
Is it safe during pregnancy or while breastfeeding?
No — pregnenolone is not recommended during pregnancy or nursing, and anyone with a hormone-sensitive condition (or on hormone-modifying medications) should consult a healthcare practitioner before use. This is a hormone-precursor formula and warrants clinical guidance.

The Science

Learn the why.

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