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FORMERLY ESTRO ZEN

Estrogen, metabolized

cleanly.

DIM Pro steers estrogen metabolism toward the 2-hydroxy pathway — the ratio your body wants. Plant-derived diindolylmethane plus calcium D-glucarate and BioPerine for absorption that actually shows up in the blood.

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Purchases are completed at Neurobiologix, the seller. Gene Direct Nutrition may earn a commission.

PROFESSIONAL GRADE · 120 CAPSULES · DIM · CALCIUM D-GLUCARATE · BIOPERINE

DIM Pro bottle
DIM
100 mg diindolylmethane

The cruciferous metabolite.

DIM is the active compound your body makes from cruciferous vegetables — at a dose you can't realistically eat. It favorably shifts the 2:16 hydroxyestrone ratio, a marker practitioners track in estrogen-dominant patients.

DETOXIFICATION
100 mg calcium D-glucarate

Phase II clearance, boosted.

Calcium D-glucarate inhibits beta-glucuronidase — the enzyme that lets conjugated estrogens re-enter circulation. The result is a cleaner path from liver to excretion.

DAILY DOSE
2 capsules (AM + PM)

Split dosing, steady levels.

One capsule in the AM, one in the PM keeps DIM at working concentration across the day. BioPerine black pepper extract improves absorption of the whole formula.

MAY BENEFIT

Hormone balance
is metabolism.

01
Estrogen metabolism
DIM shifts metabolism toward the protective 2-hydroxyestrone pathway and away from 16-alpha.
02
Hormone clearance
Calcium D-glucarate blocks re-absorption of conjugated estrogens, supporting liver-to-gut excretion.
03
Mood stability
Cleaner estrogen metabolism is linked to fewer cyclical mood swings and irritability.
04
PMS & cycle comfort
Practitioners reach for DIM in patients with bloating, breast tenderness, and irregular cycles.
05
Fat distribution support
Estrogen dominance drives abdominal and hip fat storage — rebalancing the ratio helps.
06
Cognitive clarity
Hormonal foggy thinking and memory complaints often track with estrogen metabolism quality.

Formula

Three ingredients. Targeted support for estrogen metabolism.

KEY INGREDIENTS

Calcium
from 100 mg Calcium D-Glucarate · 12 mg · 1% DV
Diindolylmethane (DIM)
100 mg
BioPerine Black Pepper Extract
95% Piperine · 1 mg

OTHER INGREDIENTS

Hypromellose (capsule), microcrystalline cellulose, ascorbyl palmitate, silicon dioxide.

DIRECTIONS

Adults: Adults take one capsule in the AM and one capsule in the PM. Children or pregnant/lactating mothers should consult a healthcare professional before use.

DIM Pro supplement facts
MAY BENEFIT:
Sexual Dysfunction
Women's Health
Hormone Balance

Questions

Frequently asked.

Who is DIM Pro designed for?
Adults dealing with signs of estrogen dominance — cyclical breast tenderness, bloating, mood swings, stubborn abdominal weight, heavy or irregular periods, or foggy thinking. It's also used in men's protocols where aromatization is a concern. Work with a practitioner to confirm the pattern.
What does DIM actually do?
DIM (diindolylmethane) shifts estrogen metabolism toward the 2-hydroxy pathway and away from 16-alpha hydroxyestrone. Practitioners track the 2:16 ratio as a marker of hormone-metabolism quality — DIM reliably moves that ratio in a favorable direction.
Can men take DIM?
Yes. Men's protocols often include DIM to support estrogen metabolism where testosterone-to-estrogen conversion is elevated. Dosing should be individualized with a practitioner.
Why calcium D-glucarate?
Calcium D-glucarate inhibits beta-glucuronidase — the gut enzyme that de-conjugates estrogens and allows them back into circulation. Paired with DIM, it supports both the metabolism and the clearance ends of the pathway.
Is it safe during pregnancy?
Children and pregnant or lactating women should consult a healthcare professional before use. DIM is not routinely recommended in pregnancy without medical oversight.
When should I expect to notice a difference?
Many patients report changes in cycle comfort and mood stability over 1-3 cycles of consistent use. Lab-tracked estrogen ratios typically improve within 8-12 weeks.

The Science

Learn the why.

hormones

Estrogen methylation: how COMT and MTHFR shape hormone balance

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Mar 20, 2026 →

pregnancy

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Folate is the single most-recommended prenatal nutrient. Here's what the research says about form (5-MTHF vs folic acid), dose, timing, and why MTHFR carriers may need a different approach — always under OB supervision.

Feb 16, 2026 →

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MTHFR and miscarriage: what the research actually shows

The link between MTHFR variants and recurrent pregnancy loss is real but frequently overstated. Here's what the meta-analyses say, why context matters, and how practitioners approach it — always with OB supervision.

Feb 6, 2026 →

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