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FORMERLY SOOTHE SUPPORT PRO

PEA,

the body's own signal.

Palmitoylethanolamide is a fatty-acid amide your tissue already makes to temper inflammation. 350 mg per capsule, paired with resveratrol, supports the resolution pathway behind nerve comfort, muscle recovery, and immune balance.

Shop PEA Soothe Support View Formula →

Purchases are completed at Neurobiologix, the seller. Gene Direct Nutrition may earn a commission.

PROFESSIONAL GRADE · 90 CAPSULES · PEA · RESVERATROL

PEA Soothe Support bottle
MECHANISM
350 mg PEA per capsule

Resolution, not blockade.

PEA does not block pain signals the way opioids or NSAIDs do. It supports the body's endogenous resolution pathway — the same chemistry your tissue uses to turn inflammation off when the job is done.

EVIDENCE
300 + human studies on PEA

A real research base.

PEA has been studied across neuropathic, musculoskeletal, and immune contexts for decades. This formula pairs it with resveratrol from Polygonum cuspidatum — a co-actor in the same lipid-signaling neighborhood.

DAILY DOSE
2 capsules daily with food

Load, then maintain.

One capsule twice daily is the maintenance dose. Some practitioners run a 2–3 week loading phase at four capsules a day to saturate the tissue before dropping to twice-daily. Discuss which fits.

MAY BENEFIT

Calm the signal,
not the patient.

01
Nerve comfort
PEA modulates mast-cell and glial activity that amplify neuropathic signaling in sensitive patients.
02
Muscle recovery
Supports the body's normal resolution response after exertion, strain, or post-viral muscle complaints.
03
Joint and connective tissue
Lipid-signaling support reaches the connective-tissue layers where chronic low-grade inflammation quietly lives.
04
Immune balance
PEA acts at the immune–nervous system interface, where mast cells and microglia shape systemic inflammatory tone.
05
Daily resilience
Non-sedating and non-stimulating — layers into protocols without touching sleep or daytime focus.
06
Drug-free support
No opioids, no NSAIDs — just a fatty-acid amide your body already makes, delivered at clinical dose.

Formula

Two ingredients. Both working the resolution pathway.

KEY INGREDIENTS

Palmitoylethanolamide (PEA)
350 mg
Resveratrol
from Polygonum cuspidatum root & rhizome extract · 50 mg

OTHER INGREDIENTS

Hypromellose, dicalcium phosphate, acacia gum, silica, and leucine complex.

DIRECTIONS

Adults: Take one capsule twice daily or as directed by your healthcare professional. For best results, take with food. For children, consult with a healthcare provider before use.

PEA Soothe Support supplement facts
MAY BENEFIT:
Inflammation
Immune System

Questions

Frequently asked.

How is PEA different from NSAIDs or opioids?
NSAIDs block cyclooxygenase enzymes and thin the mucus layer of the gut. Opioids act on central pain receptors and carry dependence risk. PEA does neither — it supports the body's own resolution chemistry, tempering mast-cell and microglial overactivity at the site of the problem. No gastric risk, no dependence profile.
What is a loading phase and do I need one?
Many practitioners run a 2–3 week loading phase at four capsules per day (1,400 mg PEA) to saturate the tissue before dropping to the twice-daily maintenance dose. Loading is especially common in neuropathic or long-standing musculoskeletal cases. Work with your practitioner to decide.
Who is this designed for?
Adults with persistent nerve, muscle, or connective-tissue complaints looking for a drug-free approach; patients sensitive to NSAIDs; those in immune protocols where resolution chemistry matters; and anyone working with a practitioner on chronic inflammatory patterns. Also useful alongside topical PEA for localized issues.
How long before I notice a difference?
PEA is cumulative — it builds tissue levels and supports resolution chemistry rather than acting as an acute analgesic. Many people report changes within 2–4 weeks of consistent use, with deeper effects through 8–12 weeks. The loading phase can shorten the on-ramp.
Can I take it with other anti-inflammatory supplements?
Yes — PEA layers well with omega-3s, curcumin, and topical PEA. Because it works on a different pathway than classic antioxidants, it tends to complement rather than duplicate their effects. Discuss your full stack with your practitioner for a coherent protocol.
Is it safe during pregnancy or while breastfeeding?
Consult your healthcare practitioner before use if you are pregnant, lactating, or managing a specific medical condition. Resveratrol in particular is not routinely recommended in pregnancy without professional oversight.

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