FORMERLY TOPICAL METHYLATION COMPLETE

Methylation,

through the skin.

For sensitive patients who can't tolerate oral B-vitamins, a topical creme delivers methylfolate, methylcobalamin, P-5-P, D3, and K1 through the skin — bypassing the gut and the first-pass liver. One pump, AM and PM.

Shop Methylation Pro Topical View Formula →

PROFESSIONAL GRADE · 120 PUMPS · METHYLFOLATE · METHYLCOBALAMIN · P-5-P · D3 · K1

Methylation Pro Topical bottle
TRANSDERMAL
120 metered pumps per bottle

Skip the gut entirely.

Methylation support through the skin — useful for patients whose gut doesn't reliably absorb oral B-vitamins, or who react poorly to sublingual and capsule forms. The airless pump protects the actives from oxidation.

ACTIVE FORMS
2 forms of methylfolate

Metafolin plus Quatrefolic.

Calcium-salt L-methylfolate and Quatrefolic glucosamine-salt L-methylfolate — two stable forms of the active folate the body can use directly, especially for MTHFR variants. Methylcobalamin and hydroxocobalamin pair in for full B12 coverage.

DAILY DOSE
2 pumps daily, AM and PM

Morning and evening rhythm.

Apply one pump in the AM, one 2-3 hours before bed, to wrists, inner forearms, inner thighs, or lower back. Wait 30 minutes before showering. Sensitive patients can start with a half-pump and titrate up.

MAY BENEFIT

Methylation runs
the whole body.

01
Mood stability
Methylation produces SAM-e, the universal methyl donor tied to serotonin and dopamine synthesis.
02
Focus & concentration
Active B12 and folate support the one-carbon chemistry behind attention and processing speed.
03
Short-term memory
Methyl-B12 supports myelin maintenance and the cholinergic signaling underlying recall.
04
Healthy sleep cycles
Methylation supports melatonin synthesis from serotonin — the chemistry behind circadian rhythm.
05
Immune function
Folate and B12 fuel rapid cell division in lymphocytes and gut epithelium.
06
Sensitive-patient tolerance
Transdermal delivery bypasses the gut issues and B-vitamin reactivity some patients experience orally.

Formula

Topical delivery. Active B-vitamins, D3, and K1.

KEY INGREDIENTS

Water
Propanediol
Vitamin E
D-Alpha Tocopherol
Polyacrylamide
C13-14 Isoparaffin
Laureth-7
Caprylic/Capric Triglycerides
Vitamin K1
Urea
Glycerin
Phenoxyethanol
Cetearyl Alcohol
Ceteareth-20
Cocos Nucifera (Coconut) Oil
Vitamin B-9 Folate
L-Methylfolate, Calcium Salt
Folinic Acid
Vitamin B6
As Pyridoxal 5'-Phosphate
Rosa Canina Fruit Extract
Citrus Aurantium Dulcis Peel Extract
Vitamin D3
Cholecaliferol
Aloe Barbadensis
Citrus Grandis Peel Oil
Gardenia Jasminoides Frustus Fruit Extract
Vitamin B12
As Methylcobalamin and Hydroxycobalamin
MSM
Methylsulfonylmethane
Sodium Hyaluronate
Panthenol
Quatrefolic
6S-5-Methyltetrahydrofolate Glucosamine Salt

OTHER INGREDIENTS

DIRECTIONS

Adults: Apply one dosage of Methylation Pro Topical twice daily or as your healthcare professional recommends. Apply one pump in the AM and one pump in the PM two-to-three hours before bedtime. Each dosage should be slightly smaller in size than a dime, approximately. For extra dosages, apply one pump three times daily - one pump in AM, one pump mid-afternoon, and one pump two-to-three hours before bedtime, or as your healthcare professional recommends.

Methylation Pro Topical supplement facts
MAY BENEFIT:
Energy
Focus & Attention
Methylation (Cell Function)
Sensory Issues
Immune System

Questions

Frequently asked.

Why apply B-vitamins topically instead of taking a capsule?
Some patients do not absorb oral B-vitamins reliably — gut inflammation, SIBO, methylation variants, or past gastric surgery can all limit uptake. Others react to oral methylfolate or methylcobalamin with overstimulation. Transdermal delivery distributes the actives more gradually through the skin, offering a gentler on-ramp.
Where should I apply it?
On thin-skinned areas with good circulation — inner wrists, inner forearms, inner thighs, or the lower back. Rotate application sites. Avoid hairy areas, which slow absorption. Wait at least 30 minutes before showering or bathing so the creme can fully absorb.
How many pumps do I need?
Standard dose is one pump AM and one pump 2-3 hours before bed. Highly sensitive patients may start with a half-pump twice daily and titrate up over a week or two. For higher need, a third mid-afternoon pump can be added under practitioner guidance.
Will this replace Methylation Complete or Methyl Folate Plus?
Not necessarily — it's an alternate delivery route for patients who don't tolerate oral B-vitamins well. Some practitioners use topical alongside oral methylation support; others substitute it for patients with gut issues. Coordinate with your healthcare provider.
Can children use it?
Yes, under the guidance of a healthcare practitioner. The metered pump allows for precise, low-dose administration that suits pediatric protocols. Half-pump starting doses are typical for children and sensitive patients.
Is it safe during pregnancy?
Active folate and B12 are critical during pregnancy, but the right dose and format should be guided by a practitioner. Consult your OB-GYN or integrative practitioner before starting any methylation support while pregnant or lactating.

The Science

Learn the why.

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