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PRECONCEPTION · PREGNANCY · POSTNATAL

Two lives,

one chemistry.

A clinically built prenatal with methylated folate, active B12, and chelated iron. Every nutrient delivered in the form the maternal body actually uses — engineered for MTHFR variants and elevated nutrient demand.

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Purchases are completed at Neurobiologix, the seller. Gene Direct Nutrition may earn a commission.

PROFESSIONAL GRADE · 90 CAPSULES · OPTIFOLIN+ · METHYL B12 · FERROCHEL IRON

Prenatal Evolved bottle
METHYLATION
1,360 mcg DFE Optifolin+®

Folate the body can use.

Optifolin+® delivers (6S)-5-methyltetrahydrofolate — the bioactive form that bypasses MTHFR bottlenecks. The folate that supports neural tube formation without the synthetic detour.

MINERALS
6 chelated Albion® minerals

Bioavailable, gentle, absorbed.

Iron as Ferrochel® bisglycinate. Zinc, selenium, copper, chromium, molybdenum as Albion® glycinate chelates. Minerals engineered for uptake without the GI distress of oxide or sulfate forms.

DAILY DOSE
3 capsules with food

Complete daily foundation.

26 micronutrients including methyl B12, choline, iodine, and K1/K2 — covering the endocrine, antioxidant, and structural demands of every trimester and the postpartum year.

MAY BENEFIT

Prenatal nutrition,
rebuilt from scratch.

01
Neural tube formation
Optifolin+® delivers active 5-MTHF directly — no MTHFR conversion required for the folate the developing nervous system needs.
02
Maternal energy
Ferrochel® iron and methylated B-vitamins support hemoglobin synthesis and the one-carbon chemistry behind sustained energy.
03
Thyroid & endocrine balance
Potassium iodide and selenium glycinate supply the cofactors behind thyroid hormone synthesis and peripheral T4-to-T3 conversion.
04
Fetal bone development
Chelated calcium, magnesium malate, vitamin D3, and K1/K2 work together to direct calcium into bone tissue.
05
Immune resilience
Zinc bisglycinate, vitamin D3, and vitamin A retinyl palmitate support immune function through the higher demands of pregnancy.
06
Brain & organ formation
150 mg choline plus methyl donors support fetal neurodevelopment and hepatic lipid handling in mother and baby.

Formula

Twenty-six micronutrients. Every form chosen for absorption.

KEY INGREDIENTS

Vitamin A
as Retinyl Palmitate, Beta Carotene · 1,500 mcg RAE · 115% DV
Vitamin C
as Ascorbic Acid, Ascorbyl Palmitate · 160 mg · 133% DV
Vitamin D
as Cholecalciferol · 25 mcg (1,000 IU) · 167% DV
Vitamin E
as d-Alpha Tocopheryl Succinate · 62 mg · 326% DV
Vitamin K
as Phytonadione · 50 mcg · 55% DV
Thiamin
as Thiamine Hydrochloride · 1.5 mg · 107% DV
Riboflavin
as Riboflavin · 1.6 mg · 100% DV
Niacin
as Niacinamide · 18 mg NE · 100% DV
Vitamin B6
as Pyridoxal 5-Phosphate · 2 mg · 100% DV
Folate
as Dicholine L-5-methyltetrahydrofolate (Optifolin+®) · 1,360 mcg DFE · 226% DV
Vitamin B12
as Methylcobalamin Dicalcium Phosphate · 10 mcg · 355% DV
Biotin
as Biotin Dicalcium Phosphate · 200 mcg · 570% DV
Pantothenic Acid
as d-Calcium Pantothenate · 20 mg · 100% DV
Calcium
as Dicalcium Malate (DimaCal®) · 100 mg · 8% DV
Iron
as Ferrous Bisglycinate Chelate (Ferrochel®) · 30 mg · 111% DV
Iodine
as Potassium Iodide · 150 mcg · 52% DV
Magnesium
as Dimagnesium Malate · 125 mg · 31% DV
Zinc
as Zinc Bisglycinate Chelate (Albion®) · 13 mg · 100% DV
Selenium
as Selenium Glycinate (Albion™) · 100 mcg · 142% DV
Copper
as Copper Bisglycinate Chelate (Albion®) · 2 mg · 154% DV
Manganese
as Manganese Bisglycinate Chelate (Albion®) · 3 mg · 115% DV
Chromium
as Chromium Nicotinate Glycinate Chelate (Albion®) · 50 mcg · 100% DV
Molybdenum
as Molybdenum Glycinate (Albion®) · 50 mcg · 100% DV
Choline
as Choline Dihydrogen Citrate · 150 mg · 27% DV
Vitamin K2
as Menaquinone-7 Dicalcium Phosphate · 90 mcg
Boron
as Boron Citrate · 100 mcg

OTHER INGREDIENTS

Hypromellose (capsule), microcrystalline cellulose, silicon dioxide.

DIRECTIONS

Adults: Adults take three capsules daily with food or as directed by a healthcare provider.

Prenatal Evolved supplement facts
MAY BENEFIT:
Women's Health

Questions

Frequently asked.

Why methylated folate instead of folic acid?
Folic acid is synthetic and requires MTHFR enzyme activity to convert into the usable form. Up to 40% of women carry MTHFR variants that slow this conversion. Optifolin+® delivers (6S)-5-methyltetrahydrofolate already in its active form — bypassing the bottleneck entirely and supporting neural tube development more reliably for genetically variable populations.
When should I start taking Prenatal Evolved?
Ideally three months before conception. Folate stores, iron status, and methylation chemistry need time to build. Continue through pregnancy and lactation — nutrient demands remain elevated while breastfeeding, and postpartum depletion is a common driver of fatigue and mood disruption.
Will this help with morning sickness?
Many prenatal formulas use iron sulfate or oxide forms that aggravate nausea. Prenatal Evolved uses Ferrochel® ferrous bisglycinate chelate — significantly gentler on the GI tract. Active B6 (Pyridoxal 5-Phosphate) and methylated B12 also support first-trimester comfort for many women.
Is the iron dose safe for women who don't need extra iron?
The 30 mg serving is within standard prenatal ranges and formulated to meet the expanded blood volume needs of pregnancy. If you have hemochromatosis or confirmed iron overload, work with your practitioner — this formula is designed for pregnant and postpartum women with typical or elevated iron needs.
Can I take this with other supplements?
Yes. Prenatal Evolved is iron-inclusive but pairs well with omega-3 (DHA/EPA), additional vitamin D if deficient, and a probiotic. Avoid stacking additional folic acid or high-dose B12 unless directed — this formula already supplies bioactive forms at clinical levels.
Is it safe while breastfeeding?
Yes — the formula is designed to support the full reproductive continuum from preconception through lactation. Maternal nutrient depletion peaks in the first year postpartum, so continued supplementation supports both maternal recovery and the nutrient density of breast milk.

The Science

Learn the why.

hormones

Estrogen methylation: how COMT and MTHFR shape hormone balance

Estrogen isn't just made — it has to be cleared. Here's how methylation (COMT and MTHFR) controls estrogen metabolism, and why it matters for hormone balance.

Mar 20, 2026 →

pregnancy

Folate in pregnancy: why form and dose matter more than you think

Folate is the single most-recommended prenatal nutrient. Here's what the research says about form (5-MTHF vs folic acid), dose, timing, and why MTHFR carriers may need a different approach — always under OB supervision.

Feb 16, 2026 →

pregnancy

MTHFR and miscarriage: what the research actually shows

The link between MTHFR variants and recurrent pregnancy loss is real but frequently overstated. Here's what the meta-analyses say, why context matters, and how practitioners approach it — always with OB supervision.

Feb 6, 2026 →

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