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BIOACTIVE B12 + FOLATE

Methylation,

in two nutrients.

5-MTHF and methylcobalamin — the bioactive forms of folate and B12 — paired on a single once-daily tablet. The backbone of methylation support for MTHFR carriers and practitioners who want a clean starting point.

Shop BioActive B12 Folate View Formula →

Purchases are completed at Neurobiologix, the seller. Gene Direct Nutrition may earn a commission.

PROFESSIONAL GRADE · 60 TABLETS · METAFOLIN 5-MTHF · METHYLCOBALAMIN

BioActive B12 Folate bottle
METAFOLIN
800 mcg 5-MTHF

Active folate, no conversion.

Metafolin is the patented 5-MTHF form your cells use directly — bypassing the MTHFR enzyme that stalls for up to 40% of the population. The activated folate folic acid can't replace.

METHYLCOBALAMIN
1000 mcg active B12

Methyl donor, ready to use.

Methylcobalamin partners with 5-MTHF in the methionine cycle — the chemistry behind homocysteine clearance, DNA repair, and neurotransmitter synthesis. No cyanocobalamin detour required.

DAILY DOSE
1 tablet with food

One tablet, full backbone.

Take one tablet daily with food. Vegetarians, seniors, and anyone with impaired absorption get a clean bypass around the GI conversion issues that standard B12 runs into.

MAY BENEFIT

Methylation is
a daily pathway.

01
Methylation support
5-MTHF and methylcobalamin drive the methionine cycle that regulates gene expression.
02
Red blood cell formation
Folate and B12 are co-dependent cofactors in erythropoiesis and iron utilization.
03
Homocysteine balance
Bioactive B12 and folate are the primary drivers of healthy homocysteine metabolism.
04
Immune function
B12 and folate support T-cell replication and the adaptive immune response.
05
Mood and cognition
Methylation regulates neurotransmitter synthesis — folate status tracks with mood quality.
06
Absorption bypass
Especially helpful for vegetarians, seniors, or anyone with impaired GI absorption.

Formula

Two activated nutrients. The methylation backbone.

KEY INGREDIENTS

Folate
As Metafolin Calcium L-5-Methyltetrahydrofolate
Vitamin B12
As Methylcobalamin

OTHER INGREDIENTS

Mannitol, Vegetable Stearine, Silicon Dioxide, Croscarmellose Sodium, Stearic Acid

DIRECTIONS

Adults: Take one tablet daily with food.

MAY BENEFIT:
Methylation (Cell Function)

Questions

Frequently asked.

Why methylfolate instead of folic acid?
Folic acid is synthetic — it requires the MTHFR enzyme to become 5-MTHF before cells can use it. If you carry an MTHFR variant, that conversion is slow or incomplete. Metafolin (5-MTHF) skips the step entirely and delivers active folate ready for the methylation cycle.
Who benefits most from this combination?
People with known MTHFR or MTRR variants, elevated homocysteine, vegetarian diets, older adults, those with GI absorption issues (celiac, IBD, gastric surgery), and anyone using methylation-focused protocols for mood, fertility, or cardiovascular support.
Can I take it with Optimal B Complex?
They're designed to be complementary — you generally pick one. BioActive B12 Folate is a focused methylation backbone; Optimal B Complex is a broader eight-B-vitamin stack that already includes methylated B12 and folate. Your practitioner can help decide which fits.
When should I take it?
One tablet daily with food, typically in the morning. Methylated B vitamins can feel mildly energizing, so morning dosing supports daytime use without disrupting sleep.
Will it help with elevated homocysteine?
Likely yes, in most patients. Bioactive B12 and 5-MTHF are the nutrients most consistently shown to bring homocysteine into range. Re-check labs after 8-12 weeks to confirm.
Is it safe during pregnancy?
Methylated B12 and folate are often recommended during pregnancy, especially for MTHFR carriers — but dosing should be individualized with your practitioner and prenatal care team.

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