VASCULAR HEALTH · CIRCULATION

Protect the pipes,

open the flow.

Eight vascular-targeted ingredients — Equol, grape seed, gotu kola, bilberry, and L-arginine — engineered to support blood vessel integrity, arterial elasticity, and the endothelial chemistry behind healthy circulation.

Shop Artery Defense View Formula →

PROFESSIONAL GRADE · 66 CAPSULES · L-ARGININE · TMG · GRAPE SEED

Artery Defense bottle
VASODILATION
200 mg L-Arginine per serving

The nitric oxide precursor.

L-Arginine is the amino acid substrate the endothelium uses to produce nitric oxide — the signaling molecule behind blood vessel dilation, smooth-muscle relaxation, and healthy peripheral circulation.

METHYLATION
200 mg TMG (Betaine)

Homocysteine in check.

Trimethylglycine donates methyl groups that recycle homocysteine back into methionine — the same chemistry that protects the vascular wall from an independent cardiovascular risk factor.

VESSEL INTEGRITY
450 mg polyphenol-rich extracts

Built for blood vessel elasticity.

Grape seed, bilberry, and gotu kola deliver proanthocyanidins and triterpene saponins studied for their role in capillary wall strength, collagen crosslinking, and LDL oxidation resistance.

MAY BENEFIT

Circulation is built,
not guaranteed.

01
Blood vessel elasticity
Grape seed and gotu kola support the collagen and elastin structure of the arterial wall under pressure.
02
Healthy nitric oxide
L-Arginine supplies the endothelial substrate behind vasodilation and peripheral blood flow.
03
Homocysteine balance
TMG donates methyl groups in the homocysteine-methionine cycle — a standalone marker of vascular aging.
04
Capillary integrity
Bilberry proanthocyanidins are studied for their role in supporting microcirculation and capillary permeability.
05
Antioxidant protection
Equol, magnesium ascorbate, and grape seed polyphenols buffer the oxidative stress behind LDL and arterial damage.
06
Arterial wall support
The combined stack addresses calcium handling, lipid oxidation, and inflammatory tone at the vascular endothelium.

Formula

Eight ingredients. Engineered for the arterial wall.

KEY INGREDIENTS

Vitamin C
as Magnesium Ascorbate · 20 mg · 22% DV
Niacin
as Niacinamide · 300 mcg · 1875% DV
L-Arginine
as L-Arginine HCl · 200 mg
Betaine Anhydrous
TMG · 200 mg
Grape Seed Extract
150 mg
Bilberry Fruit Extract
150 mg
Gotu Kola Extract
Whole Plant · 150 mg
(R,S)-Equol
6 mg

OTHER INGREDIENTS

Hypromellose (capsule), ascorbyl palmitate.

DIRECTIONS

Adults: Suggested use: Adults take two capsules once daily.

Artery Defense supplement facts
MAY BENEFIT:
Blood Vessel Function
Healthy Blood Pressure
Blood Circulation
Cardiovascular Health

Questions

Frequently asked.

How is Artery Defense different from a statin or blood pressure medication?
This formula is not a substitute for prescribed cardiovascular medication. It supports the upstream chemistry of vascular health — nitric oxide production, homocysteine recycling, antioxidant defense at the arterial wall — that complements, not replaces, medical management of diagnosed cardiovascular disease.
Why does this formula target specific gene SNPs?
Artery Defense was formulated around TNF, IL-6, STAT4, and SOCS-1 — genes tied to vascular inflammation and endothelial signaling. The polyphenol stack (grape seed, gotu kola, Equol) and methyl donor TMG were selected for their documented roles in modulating these pathways.
Who is this formula designed for?
Adults focused on long-term cardiovascular resilience — particularly those with family history of vascular disease, elevated homocysteine, MTHFR variants, or the genetic inflammatory SNPs the formula targets. Work with a practitioner if you have existing cardiovascular diagnoses or are on anticoagulant medication.
Can I take this with blood thinners or blood pressure medications?
Consult your healthcare provider. Several ingredients (grape seed, bilberry, L-arginine) can affect platelet function or blood pressure and may interact with warfarin, aspirin, or antihypertensive medications. This is a stack-under-supervision, not a stack-on-top.
How long before I notice benefits?
Vascular chemistry changes slowly. Homocysteine shifts can be measured in 4–8 weeks. Structural improvements in vessel wall tone and elasticity build over months of consistent use. Lab markers often change before subjective symptoms do.
Is this safe during pregnancy?
Consult your healthcare provider before use if pregnant or lactating. L-Arginine at supplemental doses and several of the botanicals are not routinely recommended during pregnancy without medical oversight.

The Science

Learn the why.

nutrition

Homocysteine: what drives it up, what brings it down

Elevated homocysteine is one of the most actionable labs in functional medicine. Here's what pushes it up, what pulls it down, and how to interpret your number alongside genetics and symptoms.

Feb 26, 2026 →

mthfr

MTHFR and homocysteine: the connection that actually matters

Homocysteine is the single most useful functional marker for methylation status. Here's what it is, why MTHFR carriers watch it closely, and what the numbers mean for cardiovascular, cognitive, and pregnancy risk.

Feb 23, 2026 →

nutrition

B6 forms explained: why P5P beats pyridoxine HCl

Not all vitamin B6 is the same. Here's the difference between pyridoxine HCl and P5P, why the bioactive form matters — especially for people with impaired conversion — and how to read the label.

Apr 14, 2026 →